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"The pharmacokinetic assessment you designed and executed on, really put our clinical program on track in our mission to treat rare pediatric disorders." - MID SIZE BIOTECH CLIENT

Toxicology

Type Test System
Maximum Tolerated Dose (MTD) / Dose Range Finding (DRF) Multiple Species (Mouse, Rat, Rabbit, Mini-Pig, Feline, Canine and other Research Species)
Acute / Subchronic / Chronic Multiple Species
Toxicokinetic Evaluation Validated WinNonlin
Developmental & Reproductive Toxicology (DART) Fertility (Seg I) – Mouse, Rat
Embryo-Fetal Development (Seg II) – Rat, Rabbit
Pre- and Postnatal Development (Seg III) – Rat, Rabbit
One or Two Generation – Mouse, Rat
Extended One Generation - Rat
Developmental Neurotoxicology – Mouse, Rat
Comparative Cholinesterase - Rat
Sperm analysis IVOS Analyzer (concentration, motility, morphology)
Neurotoxicology Subchronic Neurotoxicology
Developmental Neurotoxicology
- Functional Observation Battery (FOB) – Mouse, Rat
- Motor Activity
- Figure-Eight Maze – Mouse, Rat
- Cognition and Memory (Water Maze, Passive Avoidance) – Mouse, Rat
- Auditory (Startle) – Mouse, Rat
Dermal Toxicology Multiple Species
Ocular Toxicology / Ophthalmology Multiple Species
Target Animal Safety Studies(companion animal) Feline, Canine
Carcinogenicity Mouse, Rat
Pathology (in-house) Necropsy
Histology – Paraffin, Plastics
Histopathology and Immunohistochemistry (IHC)
Clinical Pathology (in-house) Hematology, Clinical Chemistry, Coagulation, Urinalysis

Pharmacokinetics (ADME)

Type Test System
Pharmacokinetic Screening (cost and time efficient) Multiple Species (Mouse, Rat, Rabbit, Mini-Pig, Feline, Canine and other Research Species)
Pharmacokinetic Evaluation Validated WinNonlin
Use of Radiolabeled Test Articles Radio-Isotopes 14C, 3H, 125I
Mass Balance / Excretion Multiple Species
Expired CO2 Collections Mouse, Rat
Cerebral Spinal Fluid Collections Multiple Species
Bile Duct Cannulated (BDC) Mode Multiple Species
Surgical Models Bile Duct Cannulation, Gastrointestinal, Portal Vein and Others
Placental and Lacteal Transfer Mouse, Rat

Safety Pharmacology

Type Test System
In-Vivo Cardiovascular Radiotelemetry (surgical capabilities in-house) Multiple Species (Rat, Rabbit, Feline, Mini-Pig, Canine, NHP)
In-Vitro - hERG Assay Patch Clamp (whole cell)
Central Nervous System Irwin – Mouse, Rat
Functional Observation Battery (FOB) – Multiple Species, Motor Activity, Figure-Eight Maze – Mouse, Rat
Cognition and Memory (Water Maze, Passive Avoidance) – Mouse, Rat
Auditory Startle – Mouse, Rat
PTZ, Metrazole Seizure Model – Mouse, Rat
Respiratory Plethysmography (head out) – Rat
Blood Gas Analysis - Multiple Species
Renal Saline-Loaded – Mouse, Rat
Clinical Chemistry (Urinalysis) - Multiple Species
Gastrointestinal GI Secretion
GI Motility (Charcoal Meal) – Mouse, Rat
Liquid Gastric Emptying – Mouse, Rat

Pharmacology

Specific Client designed models avaialble upon request for the following;

GASTROINTESTINAL
CENTRAL NERVOUS SYSTEM / PAIN
INFLAMMATION
METABOLIC DISEASES
CARDIOVASCULAR

Contact Us

Email: info@xenometricsllc.com

Phone: 913-850-5000